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A genome-wide association study demonstrated that the serine/threonine kinase encoding - ATM gene (ataxia telangiectasia mutated) has potential involvement in the mechanism of enzymes responsible for response to metformin (Zhou et al., 2011)
Hence, based on our results, we suggest that ROS play the leading role in the modification of GSH and GSSG molecules in the presence of iron complexes
Blood 81 , 22232236 (1993)
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