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Contraindications include active liver disease, severe kidney impairment, and certain neurological conditions
Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration
Both are copper tripeptides differing by one amino acid: AHK-Cu uses alanine, GHK-Cu uses glycine at the first position
PMID 9250994
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