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Long, Zeng, Shi, Tian, and Chen at West China Hospital of Sichuan University published a systematic review and meta-analysis in Free Radical Research in 2014, pooling data from 35 prospective studies involving 571,511 participants and 72,196 deaths

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In the STEP 1 trial (NEJM, 2021), semaglutide 2.4mg achieved a mean weight reduction of 14.9% over 68 weeks versus 2.4% placebo establishing a benchmark that subsequent compounds including retatrutide have sought to surpass

The time the manufacturer takes to provide the required or missing data does not count toward the 180-day target, and once this information is received, a second round of review begins, extending the total time for the review