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Thiazolidinediones (TZD) were expected to improve the asthma outcomes as they reduce insulin resistance by activating PPAR- pathways
Further, it is confirmed that liraglutide is a neuroprotective drug that can directly protect against ischemic injury in animals with diabetes mellitus
This is why it is administered only once every seven days
The PIONEER 2 and 3 trials enrolled patients with diabetes with HbA1c values between 7.0% and 10.5%, and PIONEER 4 enrolled patients with diabetes with HbA1c values between 7.0% and 9.5%
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