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Optimal dosing protocols are based on extrapolation rather than controlled human research
For individuals following a plant-based or vegetarian diet, B12 IM injections may be a preferred method of supplementation, as plant foods do not naturally contain significant amounts of B12
In addition, people that avoid animal products can be deficient in B12
In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]
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