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In human studies Astaxanthin enhanced collagen production
Data analysed by one-way ANOVA, multiple comparison, Bonferroni post hoc test ( g - o )
The theoretical rationale is that lower peak concentrations reduce GI side-effect burden
In clinical development programs, including the STEP and SURPASS trials, a higher incidence of psychiatric events was observed in the semaglutide arm of certain studies (STEP 2 and 6), although these were not prespecified endpoints, and posthoc analyses did not demonstrate a significant increase in suicidal behavior or psychiatric hospitalization [31,109,110]
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