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The greatest risk appears associated with prolonged use, with increased risks of 15- to 24-fold for 5 to 10 years or more, and this risk has been shown to persist for at least 8 to 15 years after estrogen therapy is discontinued

But stopping Ozempic can affect your blood sugar levels and may lead to a rebound of diabetes symptoms, including: increase in appetite not feeling full after eating weight gain You may also have an increased risk of cardiovascular effects, such as heart attack or stroke

Among the cited risks were not just short-term side effects but also concerns about long-term health implications due to sustained use of the drug

For patients with BMIs that started above 35, significant metabolic syndrome, or a history of yo-yo dieting, maintenance dosing often produces the best long-term outcomes