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Administration Method Both peptides require subcutaneous injection using insulin syringes
The generation, detection, and effects of reactive drug metabolites
Therefore, SGLT2-i diuretic properties show a major advantage compared to thiazides and thiazides-like diuretics, which act on the Na + CL - -cotransporter in the distal convoluted tubule, or loop diuretics, which block the Na-K-2Cl co-transporter of both the Henle loop and the macula densa, making the macula insensitive to the increased tubular sodium coming from the Henle loop
Although some trials have not found benefit, considerable evidence suggests it also provides renal protection when given intravenously prior to coronary angiography
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