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In two studies assessing patients with NASH, metformin use was associated with reduced all-cause mortality or transplantation (HR: 0.42 95% CI 0.33-0.54, total of 505 patients, figure 3)
The addition of wild type cytosol did not restore the capacity to import matrix proteins but cytosol prepared from these cell lines was functional in stimulation of peroxisomal protein import in a heterologous system
A potential solution to this challenge could lie in the topical application of sertraline or its synergistic use with established antifungals to enhance efficacy
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