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The methylation process is responsible for repairing and regenerating cells, detoxification, neurotransmitter production which influence moods and sleep, controlling homocysteine, appropriate stress response, regulating inflammation, aiding the liver in processing fats, antioxidant production, and healthy immune system function

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Again, this is where estradiol also exerts a number of direct effects on appetite, thus raising the possibility of estradiol-insulin interactions to alter food intake