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Between these two, metformin is our first-line preference as it helps not only with antipsychotic-related weight gain but also with the metabolic side effects of antipsychotics (insulin resistance, fasting glucose, triglycerides, and hyperprolactinemia), earning it a recommendation from the APA for this purpose

This has several downstream effects: slower gastric emptying (food stays in the stomach longer, extending fullness), reduced appetite signalling in the hypothalamus, and improved insulin sensitivity, which helps stabilize blood sugar and reduce cravings linked to glucose spikes and crashes

Foods To Avoid On Tirzepatide While a patient could technically eat anything when taking Tirzepatide , some foods can interfere with the drugs effectiveness or increase side effects