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J Biol Chem 268 : 26552661 Kim SO, Park JG, Lee YI (1996) Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product

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This gives receptors enough recovery time to maintain sensitivity while providing consistent stimulation during the work week