Naltrexone attenuated the increase in glutamate + glutamine to total N -acetylaspartate ratio during ketamine infusion compared to placebo ( F 1,253 = 4.83, P = 0.029) and also attenuated the reduction in Montgomerysberg Depression Rating Scale scores on day 1 (condition-by-time interaction, F 1,74 = 5.39, P = 0.023)
Increased levels of ROS and lipid peroxidation products and/or decreased levels of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, and antioxidant compounds, such as glutathione, have been reported in both NAFLD/NASH patients as well as a variety of animal models of NAFLD 9,10,11,12,13,14
Results Behavioral Tests Examination of Cognitive and Learning Abilities Using Morris Water Maze (MWM) As illustrated in Table 2 and Fig
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