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Pharmaceutical applications being explored

Consequently, exploring ferroptosis as a pivotal mechanism in dopaminergic neuron demise offers promising avenues for novel therapeutic interventions in PD

Layering an extremely restrictive diet on top of that can backfire by triggering excessive muscle loss, nutrient deficiencies, fatigue, and metabolic adaptation

Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and bloodbrain barrier penetrationusing DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entryloaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function