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A meta-analysis in Science Progress (Gupta et al., 2026) found a 3.4-fold increased risk of alopecia across 24 studies for users of GLP-1 and GIP drugs, and groups tirzepatide together with semaglutide among the agents with the highest rates

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Additionally, microglia, which are primary targets of the GLP-1R signal transduction pathway in the spinal cord, exhibit reduced activation and decreased expression of pro-inflammatory cytokines following exendin-4 treatment, suggesting therapeutic potential in monophasic EAE [113]

Drawing on current evidence and clinical experience, a synergistic approach that combines GLP-1 RAs with targeted MNT appears to be the most effective strategy to support sustainable weight loss while preserving MM