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Some genetic diseases that involve defects of transcobalamin, methylmalonyl CoA mutase, or enzymes in the pathway of cobalamin adenosylation, may also result in vitamin B12 deficiency (IOM, 2000)
Oral administration of glutathione cannot be assumed to have a physiological effect due to hydrolysis in the gastrointestinal tract, and giving large quantities of glutathione percursors such as cysteine may actually increase neurological concentrations of sulfhydryl-reactive heavy metals
When results arent immediate, the supplement gets labeled as hype. Several trials report visible skin benefits only after 812 weeks of consistent use
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