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Therapeutic strategy focusing on the ferroptosis pathway SLC7A11, a molecule that protects cancer cells from ferroptosis-induced cell death, is overexpressed in different types of cancers, including ovarian cancer, lung cancer, triple-negative breast cancer, PDAC, renal cell carcinoma, liver cancer, and glioma, and it is associated with aggressive phenotypes and poor prognosis [16,46,89]
CrossRef Diagnostic value of serum squamous cell carcinoma antigen for hepatocellular carcinoma: a systematic review and meta-analysis Jing Yu, Zhao-Juan Wang, Long-Hua Chen, Wen-Zhu Dong Scandinavian Journal of Clinical and Laboratory Investigation.2017
Hence, additional studies are needed to evaluate the entire NADPH metabolome, identify the important interrelationships and determine the main pathway to select more suitable targets
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