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A randomized, double-blind, placebo-controlled trial conducted at 96 sites in 13 countries in Asia, Europe, and North and South America, the Effect of Semaglutide 2.4 mg Once Weekly on Function and Symptoms in Subjects with Obesity-related Heart Failure with Preserved Ejection Fraction (STEP-HFpEF) trial was designed to explore whether semaglutide 2.4 mg could improve symptoms and physical function among patients with HFpEF and obesity

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15, 2022 FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight FDA.gov