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The flexible linker ensures spatial separation between the Fc region and the GLP-1 receptorbinding domain, preserving receptor accessibility and bioactivity

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Although there is no direct evidence for palmitoylation of TRAF6, it has been demonstrated that ZDHHC11 can interact with TRAF6 to promote its oligomerization and ligase activity, followed by activation of the TAK1 and IB kinase (IKK) complexes, which promotes NF-kB signaling activation in HEK293T cells (81)