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In a controlled clinical trial, 70% of women showed improved skin collagen after thigh treatment compared to 50% with vitamin C and 40% with retinoic acid
Celsius works best as an add-on to solid nutrition, training, and recovery, with progress best measured by objective metrics like a BodySpec DEXA scan
This does not diminish MOTS-c's relevance for women, but it suggests that the endpoints used to monitor response may differ
Notably, genes involved in the TSS pathway, cystine uptake and glutathione recycling (such as CBS, CSE, SLC7A11 and GSR) were DNA hypomethylated after DMF treatment 30 , supporting a regulatory effect of DMF on these pathways
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