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Dietary choline supplementation effectively suppressed airway inflammation in an allergen-induced mouse model of airway hyperreactivity by reducing eosinophil accumulation and eosinophilic peroxidase activity in bronchoalveolar lavage fluid, likely through nicotinic acetylcholine receptor activation via the cholinergic anti-inflammatory pathway ( 2.1.3 Microglia Microglia constitute specialized immune sentinels of the central nervous system that exhibit similar plasticity to macrophages, transitioning between inflammatory and anti-inflammatory phenotypes
The ROR metric serves as a quantitative indicator of the strength of association between the target drug and specific adverse events (AEs), with elevated ROR values denoting stronger statistical associations
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