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Missing doses or inconsistent timing reduces effectiveness

In December 2024, the TRIUMPH-4 Phase 3 trial results were announced, showing that participants taking retatrutide 12 mg achieved an average weight loss of 71.8 pounds or 28.7% of body weight over 68 weeks

The category is young and evolving

Recent Findings Preliminary data suggest that GLP-1 RA can modulate crucial pathways in the pathogenesis of IBD, such as chronic inflammation circuits, intestinal tight junctions, and gut microbiome dysbiosis, setting the stage for human trials to investigate the role of these agents in the treatment of IBD among people with or without diabetes and obesity