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Novel insights into the function of -cell M3 muscarinic acetylcholine receptors: therapeutic implications
GLP-1-based therapies mimic certain hormones in the gut
The SURMOUNT-1 trial, published in the New England Journal of Medicine in 2022, enrolled 2,539 adults with obesity or overweight with at least one weight-related comorbidity
In the current work, we demonstrate that a GLP-1 mimetic, exenatide, significantly improves diet-induced obesity through increased lipolysis and fatty acid oxidation of WAT in a SIRT1-dependent manner
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