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Older age, chronic medical conditions and polypharmacy in Himalayan trekkers in Nepal: an epidemiologic survey and case series

Study population and eligibility criteria We reasoned to choose as patients cohort a group of healthy obese women with polycystic ovary syndrome (PCOS) that have increased metabolic risk, in order to avoid any other concomitant clinical feature as a confounding factor, and potentially affecting the results of our study

J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

The addition of glucagon receptor agonism introduces some specific considerations not seen with GLP-1 or GIP agonists alone