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However, its future trajectory is far from linear as many uncertainties remain, e.g., acceptance of obesity as a chronic disease, budget impact faced by payers and health systems willingness and ability to pay, the readout of further cardiovascular outcomes trials after the high profile results of 2023s SELECT trial for Wegovy, or new entrants challenging first generation therapies with alternative mechanisms of action (MoA) to address shortcomings such as gastrointestinal tolerability, current drugs being injectables, or the durability and quality of weight loss which distinguishes between fat and lean body mass

These included: Nausea (most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and transient , tending to occur during the dose escalation phase and resolving or diminishing over time

Monitor response closely during the first 8 weeks

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