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Inducing ferroptosis in CD8 + T cells has been found to dampen antitumor immunity in mouse models of clone cancer (using B16 or MC38 cell line) in B6 mice [191, 192] (Fig
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Interestingly, promoting GSH synthesis with NAC treatment, which can affect early (NAPQI scavenging) and later events (scavenging of mitochondrial peroxynitrite) [32], attenuated necrotic cell death but did not induce secondary apoptosis [58]
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