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SURMOUNT-5 was a phase 3b, open-label, controlled trial in 751 adults with obesity but without type 2 diabetes, randomized 1:1 to the maximum tolerated dose of tirzepatide (10 mg or 15 mg) or the maximum tolerated dose of semaglutide (1.7 mg or 2.4 mg), once weekly for 72 weeks
Clinical judgment is still the scarce asset
GLP-1 medications mimic the action of this natural hormone in the body
Adequate water intake becomes a deliberate habit rather than an intuitive one
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