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Acute ischemic injury of astrocytes is mediated by na-k-cl cotransport and not ca2+ influx at a key point in white matter development
These medicines mimic a natural gut hormone, stimulating insulin release only when blood sugar is elevated, which reduces the risk of dangerously low glucose levels
To provide a tool for direct assessment of occupancy at the GCGR we recently developed the Positron Emission Tomography (PET) radioligand [ 68 Ga]Ga-DO3A-Tuna-2 (also known as [ 68 Ga]Ga-DO3A-S01-GCG) 7 that displayed suitable affinity and selectivity for the GCGR in rat, non-human and human liver, in combination and with negligible cross-activity on the GLP1R
Consideration: Injections require clinical administration, which provides monitoring and customization opportunities but also demands regular appointments
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