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In agreement with this, the ability of PA to protect cells against oxidative stress has been associated with inhibited ROS generation, increased GSH levels, and decreased lipid peroxidation (MDA), as shown in several studies ( An increased ROS level can directly or indirectly control the SIRT-1 enzyme ( SIRT-1 has a crucial role in modulating multiple physiological processes
Arq Bras Cardiol 117:715725
Phase II detoxification, which helps transform fat-soluble toxins into water-soluble compounds for elimination, depends heavily on adequate glutathione levels
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