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Additionally, people with kidney or liver disease, iron or folic acid deficiencies or bone marrow-affecting conditions should consult their doctor before using B12 injections[18]

Conditions such as atrophic gastritis (thinning of the stomach lining), Pernicious anemia (which makes it harder for your body to absorb Vitamin B12), Intestinal diseases such as crohns disease, celiac disease, bacterial growth and immune system disorders such as Graves disease or lupus can lead to Vitamin B12 deficiency in the body

No, they arent miracle supplements by themselves, but if used appropriately and as part of a comprehensive treatment plan they can be very powerful

British Journal of Haematology