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Conditions, such as pregnancy, in which estradiol levels are high, are a high-risk time where susceptible women are more at risk of developing metabolic comorbidities such as obesity and gestational diabetes

People with lower BMI have less excess fat to lose, making the side effect burden less justified for the marginal additional weight loss at higher doses

The regulatory story is not simple, but understanding it is essential for researchers who want to operate within legal frameworks while accessing the compounds they need for their work