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Principal componentbased epigenetic clocks (PCHorvath1, PCHorvath2, PCHannum, PCPhenoAge, PCGrimAge) were calculated using the PC-Clocks repository ( Non-PC Horvath, Hannum, and DNAmPhenoAge clocks were calculated using the methyAge function in the ENmix R package (v1.44.3)

Marzo-Ortega, H

How tirzepatide works: Activates GLP-1 and GIP pathways Enhances insulin response Strongly suppresses appetite Improves energy metabolism Benefits of tirzepatide include: Greater weight loss potential compared to GLP-1 alone Improved blood sugar regulation Enhanced fat metabolism Long-lasting appetite control Many patients who do not respond fully to semaglutide may benefit from tirzepatide due to its dual mechanism

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