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Its antihyperglycemic properties were first discovered in 1918, and in 1957, Jean Sterne successfully used it to treat diabetes mellitus (2)
The approaches are mechanistically contradictory exogenous HGH suppresses pituitary GH production, which would blunt the secretagogues' mechanism of action
First-generation GLP-1 receptor agonists necessitated once or twice-daily dosing, resulting in substantial peak-to-trough variations that caused inconsistent glycaemic regulation and heightened gastrointestinal adverse effects (Nauck and Meier 2019)
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