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consider for patients with pre-existing liver disease, hepatic risk factors, or when starting antidepressants with specific hepatic cautions (e.g., duloxetine in patients with risk factors) Periodic monitoring follow the mandatory schedule for agomelatine (baseline, 3, 6, 12, and 24 weeks)
However, structural malformations, including craniofacial defects and reduced fetal weights occurred in offspring of multiple species of pregnant animals administered topiramate at clinically relevant doses (see Data)
A double-blind, placebo-controlled RCT of targeted oral naltrexone enrolled 120 sexual and gender minority men with mild to moderate AUD a targeted, biomarker-adjacent population and that study design reflected the ongoing tension in addiction pharmacotherapy between population specificity and label breadth
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