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Active malignancy NAD+ supports cellular proliferation, including potentially in cancer cells
Since SIRT1 has antioxidant, anti-inflammatory, and genomic stability effects, and it is highly expressed in microglia and neurons in the human brain (Cho et al
The potential mechanisms underlying this effect include the drugs water solubility, which facilitates its passage through cell membranes, as well as its uptake via OCTs and excretion with the assistance of multidrug and toxin extrusion (MATE) proteins
& Thaiss, C
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