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A 7-fold increase in bioavailability means that a 500 mcg oral dose of the arginate form could deliver the equivalent systemic exposure of approximately 3,500 mcg of the acetate form taken orally
doi: 10.4236/wjv.2017.74004 253 ZhangSPaulSKunduP
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To examine molecular mechanisms of this phenomenon, exendin (939)specific inhibitor of GLP-1 receptor, Rp-cAMPthe cAMP inhibitor, PI3 K inhibitor LY294002 or p44/42 mitogen-activated protein kinase inhibitor UO126, were given concomitantly with GLP-1 + VP infusion
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