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This voluntary model allows manufacturers to enter negotiated agreements with CMS to provide set pricing on their portfolio of covered outpatient drugs using the MFN pricing
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However, this is where many people run into a brick wall
Eli Lillys GLP-1 offering, tirzepatide, launched shortly after (as Mounjaro for T2D in 2022 and Zepbound for obesity in 2023), demonstrated greater HbA1c reduction and up to a 20% placebo-adjusted weight loss
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