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In some cases, they couldn't find any published clinical studies in humans and there were safety concerns like the potential to encourage cancer growth or to trigger a massive immune response
It leads to clogged pores, blackheads, whiteheads, cysts, and sometimes scarring
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The structures were refined by combining manual adjustments in Coot v0.9.8.3 66 and ISOLDE 67 in UCSF ChimeraX 1.6.1 68 , followed by real-space refinement in PHENIX v1.20.1-4487 69 with Ramachandran, rotamer, torsion, and secondary structure restraints enforced
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