TB-500 reproduces the active region (the sequence Ac-LKKTETQ) of Thymosin Beta-4 , a protein tied to actin regulation, cell migration and wound healing
View Source Annals of the New York Academy of Sciences Thymosin beta-4: actin regulation and more 2005 DOI: 10.1196/annals.1359.005 PMID: 16399924 Goldstein AL, Hannappel E, Kleinman HK View Source BioMed Research International GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration 2015 DOI: 10.1155/2015/648108 PMID: 26236485 Pickart L, Vasquez-Soltero JM, Margolina A View Source Gastroenterology PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation 2008 DOI: 10.1053/j.gastro.2007.10.026 PMID: 18164718 Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al
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In this manner, they are signalling mediators by reacting with redox-regulated proteins, but they can act as damage/signalling agents in many different physiological situations, including root injury, programmed cell death, senescence, stomata response to abscisic acid, and root response to auxin
