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Beta blockers can be taken concurrently with retatrutide, but they may not fully control the heart rate increase because retatrutide works through the glucagon receptor cAMP-PKA pathway rather than the sympathetic nervous system that beta blockers target
PMID 12361945
SGLT2 inhibitors (empagliflozin, dapagliflozin, canagliflozin) and GLP-1 receptor agonists are the classes with the strongest kidney safety and protective evidence in type 2 diabetes
[1] Because the vial contains benzyl alcohol as a preservative, it is contraindicated in neonates and infants
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