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PubMed 18061177 PMC2431115 TB-4 / TB-500 product mislabeling documented bidirectional mislabeling between full-length TB-4 (43 aa) and the TB-500 fragment (residues 1723) in marketed peptide products: Esposito M et al

This process consumes cellular methyl donors and, critically, prevents nicotinamide from being recycled into NAD+

This neurotropic combination (Thiamine B1 + Pyridoxine B6 + Cyanocobalamin B12) is used for: peripheral neuropathy (diabetic/alcoholic), nerve compression syndromes, vitamin deficiency states, and chronic pain management

These effects occur without elevating IGF-1 or affecting carbohydrate metabolism, differentiating it from full-length HGH in terms of safety and selectivity