The molecular mechanisms of the neuroprotective effects of GLP-1R agonists include signaling pathways such as ERK signaling, PI3K signaling, RhoA activity, MAPK/NF-B signaling, and the Epac/Akt pathway
With Wegovy, interactions can happen because the medicine: Slows your stomach emptying Changes your appetite and eating patterns Affects the regulation of your blood sugar Can lead to nausea, vomiting, or diarrhoea When your digestion slows down, some of the oral medicines you are taking may take longer to absorb by your body
Experts say these side-effects can relate to the way the medications work: slowing the progress of food through the digestive tract, slowing stomach emptying and affecting signalling from the gut to the brain
Journal of Pakistan Association of Dermatologists, July-September 2016, ePublication 6