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GHK-Cu acts upstream of collagen synthesis by stimulating fibroblast activity and matrix gene expression
Therefore, the clearance of senescent cells through apoptosis is one of the proposed mechanisms to reduce the burden imposed by the presence of senescent cells and in consequence, prevent age-related diseases and ultimately revert aging 3
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Human adult dermal fibroblasts incubated with GHK-Cu at concentrations of 0.01, 1, and 100 nM demonstrated increased production of both elastin and collagen, with all concentrations increasing TIMP1 expression and low concentrations enhancing MMP1 and MMP2 gene expression
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