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Without enough mitochondrial capacity, even a perfect signal from Retatrutide produces a backed-up system where mobilized fat doesnt get oxidized
An MJFF-funded Phase IIb placebo-controlled trial did show mild benefit but because the placebo group also improved, the significance of these results is unclear
Human studies used small and heterogeneous populations
When activated, Nrf2 binds to the antioxidant response elements in our DNA, triggering the production of powerful endogenous antioxidant enzymes like superoxide dismutase, catalase, and glutathione peroxidase
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