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We highlight how single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics have unveiled unprecedented cellular heterogeneity, delineated pathogenic trajectories like maladaptive tubular cell states, and established immune dysregulation as central to disease progression
Conclusions The natural history of kidney disease in nephropathic cystinosis, involving Fanconi syndrome in infancy and glomerular failure at approximately 10 years of age, has been well-documented
Most importantly, never skip sunscreenuse SPF 30 or higher daily, reapply every 2 hours outdoors, and consider physical sunscreens if chemical formulas cause irritation
At 6 wk of age, mice underwent a battery of behavioural tests (described in detail below) while treatment continued
