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Rather than stopping entirely and risking the weight regain documented in the STEP 1 extension trial (Wilding et al., Diabetes Obes Metab, 2022), where participants regained two-thirds of lost weight within one year of stopping, a microdose may provide enough GLP-1 receptor activation to maintain the appetite set-point shift
The broader question extends beyond semaglutide
Always consult a qualified healthcare provider before making decisions about any medication or treatment
The GH-IGF1 axis keeps showing up in peptide medicine because it links visceral fat, recovery, and lean mass
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