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Chronic elevation of cortisol levels , as seen in Cushing's syndrome, is associated with multiple adverse effects including: Central obesity and metabolic syndrome Insulin resistance and type 2 diabetes Hypertension and cardiovascular disease Osteoporosis and increased fracture risk Mood disturbances, anxiety, and depression Impaired immune function and wound healing Psychological stress can affect cortisol patterns, though the relationship is complex and varies between individuals
While the C-terminus of oxyntomodulin and the receptor ECD/ECL1 was lower resolution in the cryo-EM map, the interaction patterns in the modelled protein and the MD simulations were largely similar to GLP-1, albeit that the nature of some interactions differed due to their differing sequences
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