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10.1097/00003086-199302000-00042 58 KawaiT.MiekiA.OhnoY.UmemuraM.KataokaH.KuritaS.et al (1993)
The peptide upregulates MMP-2 expression in dermal fibroblasts by 85%, facilitating breakdown of damaged collagen and enabling cellular migration through dense matrix environments, while simultaneously enhancing production of tissue inhibitors of metalloproteinases (TIMPs) to prevent excessive degradation
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