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[1] Bi-Amino Injections clinical rationale draws on pharmacokinetic evidence that intravenous arginine produces a sharp plasma peak followed by biphasic clearance, whereas citrulline bypasses splanchnic arginase activity, undergoes efficient renal conversion back to arginine, and sustains substrate availability for nitric-oxide synthase several hours beyond the initial infusion

Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex

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