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The pattern is consistent: researchers who follow a structured titration protocol with pre-specified timing windows report cleaner data and fewer early discontinuations due to adverse events
The larger treatment effect reported by the authors of the Lixisenatide study (that manifested in trial participants younger than age 60), will need to be further investigated
Plant Physiol 124(1):461473 Hibi T, Nii H, Nakatsu T, Kimura A, Kato H, Hiratake J, Oda J (2004) Crystal structure of g-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
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